accelerating research

Featured Publication

December 2019

Han, L, Bittner, S, Dong, D, Cortez, Y, Dulay, H, Arshad, S, Shen, W, Kraemer, FB, & Azhar, S

Akheruzzaman, M, Hegde, V, Siddik, MAB, Feizy, Z, Shin, AC, & Dhurandhar, NV (2022). E4orf1-induced reduction in endogenous insulin level is independent of pancreas endocrine function. International Journal of Obesity, 1-8.

Albers, RE, Kaufman, MR, Natale, BV, Keoni, C, Kulkarni-Datar, K, Min, S, Williams, CR, Natale, DRC & Brown, TL  (2019) Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction. Scientific Reports 9, 2742.

Binnewies, M, Pollack, JL, Rudolph, J, Dash, S, Abushawish, M, Lee, T, … & Sriram, V (2021). Targeting TREM2 on tumor-associated macrophages enhances immunotherapy. Cell Reports 37(3), 109844.

Boehme, SA, Franz-Bacon, K, DiTirro, DN, Ly, TW, & Bacon, KB (2016) MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis. PLoS ONE 11(5): e0154874.

Boehme, SA, Franz-Bacon, K, Ludka, J, DiTirro, DN, Ly, TW, & Bacon, KB (2016) MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction. PLoS ONE 11(12): e0167169.

Branche, E, Simon, AY, Sheets, N, Kim, K, Barker, D, Nguyen, AT, Sahota, H, Young, MP,  Salgado, R, Mamidi, A, Viramontes, KM, Carnelley, T, Qiu, H, Ngono, AE, Regla-Nava, JA, Susantono, MX, Valls Cuevas, JM, Kennedy, K, Kodihalli, S, & Shresta, S  (2019) Human Polyclonal Antibodies Prevent Lethal Zika Virus Infection in Mice. Scientific Reports 9, 9857.

Butt, NA,  Kumar, A, Dhar, S,  Rimando, AM, Akhta, I, Hancock, JC, Lage, JM,  Pound, CR, Lewin JR, Gomez, CR, & Levenson, AS (2017) Targeting MTA1/HIF‐1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression. Cancer Medicine 6(11), 2673-2685.

Chow, A, Schad, S, Green, MD, Hellmann, MD, Allaj, V, Ceglia, N, … & Merghoub, T (2021). Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity. Cancer Cell.

Dewar, H, Snodgrass, OE, Muhling, BA, & Schaefer, KM. (2022). Recent and historical data show no evidence of Pacific bluefin tuna reproduction in the southern California Current system. PloS one, 17(5), e0269069.

Dhar, S,  Kumar, A, Gomez, CR,  Akhtar, I, Hancock, JC,  Lage, JM, Pound, CR, & Levenson, AS (2017) MTA1‐activated Epi‐microRNA‐22 regulates E‐cadherin and prostate cancer invasiveness. FEBS Letters 591(6), 924-933.

Dillon, GM, Tyler, WA, Omuro, KC, Kambouris, J, Tyminski, C, Henry, S, Haydar, TF, Beffert, U, & Ho, A (2017) CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Neuron 93(6), 1344-1358.

Elbadawi M, Gaisford S, Basit AW. Advanced machine-learning techniques in drug discovery. Drug Discovery Today. 2020 Dec 5.

Frietze, KK, Brown, AM, Das, D, Franks, RG, Cunningham, JL, Hayward, M, & Nickels Jr, JT (2021). Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death. Autophagy, 1-19.

Gadkari, K., Kolhatkar, U., Hemani, R., Campanelli, G., Cai, Q., Kumar, A., & Levenson, A. S. (2020). Therapeutic Potential of Gnetin C in Prostate Cancer: A Pre-Clinical StudyNutrients12(12), 3631.

Geisz A & Sahin-Tóth, M  (2018) A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation. Nature Communications 9, 5033.

Han, L, Bittner, S, Dong, D, Cortez, Y, Dulay, H, Arshad, S, Shen, W, Kraemer, FB, & Azhar, S (2019) Creosote bush-derived NDGA attenuates molecular and pathological changes in a novel mouse model of non-alcoholic steatohepatitis (NASH). Molecular and Cellular Endocrinology 498. DOI: 10.1016/j.mce.2019.110538.

Hilton, HG, Rubinstein, ND, Janki, P, Ireland, AT, Bernstein, N, Wright, KM, Finkle, D, Martin-McNulty, B, Roy, M, Smith, M, Imai, DM, Jojic, V, & Buffenstein, R (2019) Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity. bioRxiv, Apr. 4, 2019; doi:

Ho, EV, Shi, C, Cassin, J, He, MY, Nguyen, RD, Ryan, GE, … & Mellon, PL (2021). Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells. Endocrinology 162(12), bqab197.

Hoffmann, HM, Meadows, JD, Breuer, JA, Yaw, AM, Nguyen, D, Tonsfeldt, KJ, … & Mellon, PL (2021). The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. Journal of Neuroscience Research.

Ji, J, Judkowski, VA, Liu, G, Wang, H, Bunying, A., Li, Z, Xu, M, Bender, J, Pinilla, C, & Yu, JS (2014) Identification of Novel Human Leukocyte AntigenA*0201-Restricted, Cytotoxic T Lymphocyte Epitopes on CD133 for Cancer Stem Cell Immunotherapy. Stem Cells Translational Medicine 3, 356–364.

Kianna Y. Elahi-Gedwillo, KY, Marjorie Carlson, M, Jon Zettervall, J, & Provenzano, PP (2019) Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma. Cancer Research 79(2), 372-386.

Kim, M, Morales, LD, Lee, CJ, Olivarez, SA, Kim, WJ, Hernandez, J, Mummida, S, Jenkinson, C, Tsin, AT, Jang, I, Slaga, TJ, & Kim, D (2020). Overexpression of TC-PTP in murine epidermis attenuates skin tumor formation. Oncogene, 1-16.

Kumar, A,  Dhar, S, Campanelli, G,  Butt, NA Schallheim, JM, Gomez, CR, &  Levenson, AS (2018) MTA1 drives malignant progression and bone metastasis in prostate cancer. Molecular Oncology 12(9), 1596-1607.

Lefèvre, P, Guizzetti, L, McKee, TD, Zou, G, van Viegen, T, McFarlane, SC, … & Casteele, NV. (2022). Development and Validation of a Digital Analysis Method to Quantify CD3-immunostained T Lymphocytes in Whole Slide Images of Crohn’s Disease Biopsies. Applied Immunohistochemistry & Molecular Morphology, 10-1097.

Luchtel, RA, Bhagat, T, Pradhan, K, Jacobs, WR, Levine, M, Verma, A, & Shenoy, N (2020) High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model. Proceedings of the National Academy of Sciences of the United States of America, Jan, 7, 2020; DOI: 10.1073/pnas.1908158117.

Lyman, M, Lieuw, V, Richardson, R, Timmer, A, Stewart, C, Granger, S, Woods, R, Silacci, M, Grabulovski, D, & Newman, R (2018) A bispecific antibody that targets IL-6 receptor and IL-17A for the potential therapy of patients with autoimmune and inflammatory diseases. Journal of Biological Chemistry 293(24), 9326-9334.

Marella, M, Yao, X., Carreira, V, Bustamante, MF, Clark, HB, Jackson, CC, … & Cornax, I (2022). Comprehensive BCMA expression profiling in adult normal human brain suggests a low risk of on-target neurotoxicity in BCMA-targeting multiple myeloma therapy. Journal of Histochemistry & Cytochemistry, 70(4), 273-287.

Marvin K, Schwartz I, Utz E, Wilson J, Johnson C, Gaudreau P. Effects of Fractional CO2 Laser Treatment on Subglottic Scar in a Rabbit Model. Otolaryngology–Head and Neck Surgery. 2020 Dec 8:0194599820978256.

Nag, D, Farr, D, Raychaudhuri, S, & Withey, JH. (2022). An adult zebrafish model for adherent-invasive Escherichia coli indicates protection from AIEC infection by probiotic E. coli Nissle. iScience, 25(7), 104572.

Petri, BJ, Piell, KM, Whitt, GCS, Wilt, AE, Poulton, CC, Lehman, NL, … & Klinge, CM. (2021). HNRNPA2B1 regulates tamoxifen-and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. Cancer Letters518, 152-168.

Proia, DA, Smith, DL, Zhang, J, Jimenez, J-P, Sang, J, Ogawa, LS, Sequeira, M, Acquaviva, J, He, S, Zhang, C, Khazak, V, Astsaturov, I, Inoue, T, Tatsuta, N, Osman, S, Bates, RC, Chimmanamada, C, & Ying, W (2015) HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors. Molecular Cancer Therapeutics 14(11), 2422-2432.

Raouf, S, Weston, C, Yucel, N, & Reproducibility Project: Cancer Biology (2015) Registered report: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. eLife e04105. DOI: 10.7554/eLife.04105.

Ridgway, SH, Brownson, RH, Van Alstyne, KR, & Hauser, RA (2019) Higher neuron densities in the cerebral cortex and larger cerebellums may limit dive times of delphinids compared to deep-diving toothed whales. PloS one, 14(12).

Schommer, NN, Nguyen, J, Yung, BS, Schultheis, K, Muthumani, K, Weiner, DB, Humeau, L, Broderick, KE, & Smith TRF (2019) Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation. Human Gene Therapy 30(4) 523-533.

Shields, BD, Koss, B, Taylor, EM, Storey, AJ, West, KL, Byrum, SD, Mackintosh, SG, Edmondson, R, Mahmoud, F, Shalin, SC, & Tackett, AJ (2019) Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer Research 79(6), 1113-1123.

Stevens, WG, Gould, DJ, Pham, LD, & Jimenez Lozano, JN (2021). Molecular and Histological Evidence Detailing Clinically Observed Skin Improvement Following Cryolipolysis. Aesthetic Surgery Journal.

Verco, J, Johnston, W, Frost, M, Baltezor, M, Kuehl, PJ, Lopez, A, Gigliotti, A, Belinsky, SA, Wolff, R, & diZerega, G (2019) Inhaled Submicron Particle Paclitaxel (NanoPac) Induces Tumor Regression and Immune Cell Infiltration in an Orthotopic Athymic Nude Rat Model of Non-Small Cell Lung Cancer. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32(5), 266-277.

Wallace EM, Rizzi, JP, Han, G,  Wehn, PM, Cao, Z Du, X, Cheng, T,  Czerwinski, RM, Dixon, DD, Goggin, BS,  Grina, JA, Halfmann, MM, Maddie, MA, Olive, SR, Schlachter, ST, Tan, H, Wang, B, Wang, K, Xie, S,  Xu, R, Yang, H & Josey, JA (2016) A Small-Molecule Antagonist of HIF2a Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Research 76(18), 5491-5500.

Wang H, Hoffman C, Yang X, Clapp B, Pascual DW (2020) Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection. PLoS pathogens, 16(1):e1008176.

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