Resources

Reveal Biosciences and QuantumCyte Partner to Offer a New Generation of Multi-omic Data

Precision medicine has come a long way towards benefiting patient outcomes and enhancing research tools. In recent years, the integration of multi-scale omics from genomic, proteomic, and transcriptomic foundations has impacted how biological pathways and disease progression are studied. The industry has rapidly progressed due to both improved, ultra-sensitive technologies and increased awareness across expert …

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imageDx: NASH – A New Generation of Quantitative NASH Data

Traditional NAFLD Activity Scoring Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent causes of liver dysfunction, with some estimates suggesting up to 30% of the general population as being affected (1). NAFLD, while mainly asymptomatic, can progress to non-alcoholic steatohepatitis (NASH) in a portion of individuals. NASH is characterized by multiple pathologic …

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Spheroids: Research in 3D

What Are Spheroids? A spheroid is a small, spherical cluster of cells that acts as a 3D cell culture. The term “organoid” is also used interchangeably with “spheroid”, although the former specifically refers to a 3D cluster of organ-specific cells. Spheroids and organoids can be artificially assembled through different methods, including the use of centrifugal …

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Inside the Slide: Episode 1

We are proud to present the premier episode of our “Inside the Slide” video series. In this first episode, we examine a whole slide image of a prostate tissue sample stained with hemotoxylin and eosin (H&E). In the coming months, we will explore more whole slide images of different tissue types and staining techniques we …

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Precision Histology: Artificial Intelligence as a Tool for Pathologists

The hematoxylin and eosin (H&E) stain has long been an essential tool in the pathologist’s arsenal. Positively-charged hematoxylin and negatively-charged eosin bind to different substances within a tissue sample. This allows pathologists to clearly view different structures within that sample in various shades of blue, violet, and red. Once stained, the tissue sample can be …

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Mid-IR Microscopy for Biopharma

A Novel Class of Label-free Tissue Analysis Mid infrared (IR) microscopy is a well-established technique in spectroscopy and life sciences; however, until recently sample throughput and interpreting the large amount of data generated have been prohibitive in translating this technology into routine use. New technological advancements in mid-IR microscopy help solve this problem by allowing …

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Orthotopic PDX Models with Quantitative Pathology End Points in Translational Oncology Research

Orthotopic Patient-Derived Xenografts (PDX) Despite the rise of personalized approaches to the treatment of cancer, translating these therapies into a clinical setting still poses an exceptional challenge. This is highlighted in drug development where research into targeted therapies requires highly characterized tools that mimic human tumors as closely as possible. Patient-derived Xenografts (PDXs) are one …

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Case Study: Customized IHC Antibody Validation Services for Antibody Manufacturers

CASE STUDY Cancer R&D researchers have adopted the use of immunohistochemistry (IHC) tests for research, prognostic and diagnostic use at an extremely fast rate (1). Despite these statistics, many antibody vendors targeting these researchers do not validate whether or not their antibodies can be employed in an IHC test. This is of concern since antibodies …

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